Re: [SwarmFest2004] SwarmFest 2004 Abstract

[Rick Riolo]

hi jose,
ok, we have your abstract,
thanks,
  - r

Rick Riolo                           address@hidden
Center for the Study of Complex Systems (CSCS)
4477 Randall Lab
University of Michigan         Ann Arbor MI 48109-1120
Phone: 734 763 3323                  Fax: 734 763 9267
http://cscs.umich.edu/~rlr

On Wed, 31 Mar 2004, Jose L Segovia-Juarez wrote:

> Date: Wed, 31 Mar 2004 19:01:02 -0500 (EST)
> From: Jose L Segovia-Juarez <address@hidden>
> To: address@hidden
> Cc: Jose L Segovia-Juarez <address@hidden>,
>      address@hidden, address@hidden
> Subject: [SwarmFest2004] SwarmFest 2004 Abstract
>
> Dear SwarmFest2004 Organizing Committee:
>
>   We are submitting the following abstract to
> be considered for a talk at SwarmFest 2004.
>
> Title: "An agent-based model to study tuberculosis granuloma
>         formation in the lung".
>
> Authors: Jose L. Segovia-Juarez(1), Suman Ganguli(2), and
>          Denise Kirschner(1)
>
> (1) Department of Microbiology and Immunology, University of Michigan,
>     Ann Arbor, MI 48109, USA.
> (2) Biosystems Group, Department of Biopharmaceutical
>     Sciences, University of California San Francisco, San Francisco, CA
>     94143, USA.
>
>   Best regards,
>
> Jose
>
> ------------------------------------------------------------
> ABSTRACT
>
> An agent-based model to study tuberculosis granuloma formation in the lung
>
> Jose L. Segovia-Juarez(1), Suman Ganguli(2), and Denise Kirschner(1)
>
> (1) Department of Microbiology and Immunology, University of Michigan,
>     Ann Arbor, MI 48109, USA.
>     http://malthus.micro.med.umich.edu/lab/
>
> (2) Biosystems Group, Department of Biopharmaceutical
>     Sciences, University of California San Francisco, San Francisco, CA
>     94143, USA.
>
>
> Infection with Mycobacterium tuberculosis is a major world health
> problem. An estimated 2 billion people are presently infected and the
> disease causes approximately 3 million deaths per year. After bacteria
> are inhaled into the lung, a complex immune response is triggered
> leading to the formation of multicellular structures called
> granulomas.  The understanding of granuloma formation in the lung is
> key for improving diagnostic and treatment of the disease. There are
> several cells types and chemical factors involved in granuloma
> formation: macrophages, CD4 and CD8 T-cells, several chemokines and
> cytokines. We have developed an agent-based model to study this
> complex biological system.  The model, implemented in C++, combines
> continuous representations of chemokines, and discrete representation
> of macrophages, T-cells in a cellular automata like environment.  A
> two dimensional array represents the lattice. Each element of the
> array contains macrophages, T cells, chemokine and bacteria.  Objects
> were created for macrophages and T cells. Real variables were used for
> extracellular bacteria and chemokine concentrations. We established a
> set of rules to govern the dynamics of the system, representing the
> biological interactions of the entities. Our results indicate that key
> host elements involved in granuloma formation are chemokine diffusion,
> macrophage overcrowding the granuloma, number of T cells within the
> granuloma, and an overall host ability to activate macrophages.
>
>
>
> -------------------------------------
>
> _______________________________________________
> SwarmFest2004 mailing list
> address@hidden
> http://www.swarm.org/mailman/listinfo/swarmfest2004
>